发明授权
US6133299A Methods for treating neurodegenerative diseases and disorders using
N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other
anticonvulsant compounds
失效
使用N-（2,6-二取代芳族）-N'-吡啶基脲和其他抗惊厥化合物治疗神经变性疾病和病症的方法
- 专利标题： Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
- 专利标题（中）： 使用N-（2,6-二取代芳族）-N'-吡啶基脲和其他抗惊厥化合物治疗神经变性疾病和病症的方法
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申请号： US23016申请日： 1993-02-25
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公开(公告)号： US6133299A公开(公告)日： 2000-10-17
- 发明人: Charles Price Taylor, Jr. , Mark Lawrence Weber
- 申请人： Charles Price Taylor, Jr. , Mark Lawrence Weber
- 申请人地址： NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： NJ Morris Plains
- 主分类号： A61K31/165
- IPC分类号： A61K31/165 ; A61K31/415 ; A61K31/425 ; A61K31/44 ; A61K31/53 ; A61K31/55
摘要：
The instant invention is novel uses of known N-(2,6-disubstituted phenyl)-N'-3- and 4-pyridinyl ureas and pharmaceutically acceptable acid addition salts thereof. Such compounds as N-(2-chloro-6-methylphenyl)-N'-4-pyridinyl urea monohydrochloride or N-(2,3-dichlorophenyl)-N'-4-pyridinyl urea are used for treating neurodegenerative disorders, perinatal asphyxia, Alzheimer's disease, Huntington's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. The instant invention is similar novel uses of known anticonvulsant compounds as ralitoline, phenytoin, lamotrigine, tetrodotoxin, lidocaine, and carbamazepine.
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