发明授权
- 专利标题： Formulation for paclitaxel
- 专利标题（中）： 紫杉醇制剂
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申请号： US427153申请日： 1999-10-25
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公开(公告)号： US6136846A公开(公告)日： 2000-10-24
- 发明人: Joseph Rubinfeld , Ashok Y. Gore , Rajashree Joshi , Rajesh Shrotriya
- 申请人： Joseph Rubinfeld , Ashok Y. Gore , Rajashree Joshi , Rajesh Shrotriya
- 申请人地址： CA San Ramon
- 专利权人： Supergen, Inc.
- 当前专利权人： Supergen, Inc.
- 当前专利权人地址： CA San Ramon
- 主分类号： A61K9/08
- IPC分类号： A61K9/08 ; A61K9/107 ; A61K9/48 ; A61K31/337 ; A61K47/04 ; A61K47/10 ; A61K47/12 ; A61K47/22 ; A61K47/34 ; A61K47/40 ; A61K47/48 ; A61P35/00 ; A61K31/335
摘要：
A pharmaceutical formulation is provided for delivering paclitaxel in vivo comprising: water and micelles comprising paclitaxel and a pharmaceutically-acceptable, water-miscible solubilizer forming the micelles, the solubilizer selected from the group consisting of solubilizers having the general structuresR.sub.1 COOR.sub.2, R.sub.1 CONR.sub.2, and R.sub.1 COR.sub.2,wherein R.sub.1 is a hydrophobic C.sub.3 -C.sub.50 alkane, alkene or alkyne and R.sub.2 is a hydrophilic moiety. The solubilizer is selected such that it does not have a pKa less than about 6.
公开/授权文献
- US5680676A Kitchen utensil handle 公开/授权日：1997-10-28
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