- 专利标题： Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith
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申请号： US105907申请日： 1998-06-26
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公开(公告)号： US6140050A公开(公告)日： 2000-10-31
- 发明人: Ugur Sahin , Ozlem Tureci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
- 申请人： Ugur Sahin , Ozlem Tureci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
- 申请人地址： NY New York
- 专利权人： Ludwig Institute for Cancer Research
- 当前专利权人： Ludwig Institute for Cancer Research
- 当前专利权人地址： NY New York
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; C12Q1/68 ; G01N33/574 ; C07H21/04 ; C12P19/34
摘要：
The invention relates to assays for determining breast cancer or melanoma. It has been found that the accuracy of such assays can be improved by assaying samples for three or more known tumor rejection antigen precursors. For breast cancer, the tumor rejection antigen precursors known as SCP-1, NY-ESO-1, and SSX-2 are assayed. For melanoma, SSX-2, NY-ESO-1, and MAGE-3 are assayed. Additional known tumor rejection antigen precursors can also be determined to confirm the assays. It is preferred to carry these out via polymerase chain reactions.
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