发明授权
- 专利标题: Dolastatin 15 derivatives
- 专利标题(中): Dolastatin 15衍生物
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申请号: US896394申请日: 1997-07-18
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公开(公告)号: US6143721A公开(公告)日: 2000-11-07
- 发明人: Bernd Janssen , Teresa Barlozzari , Andreas Haupt , Thomas Zierke , Andreas Kling
- 申请人: Bernd Janssen , Teresa Barlozzari , Andreas Haupt , Thomas Zierke , Andreas Kling
- 申请人地址: DEX Rheinland-Pfalz
- 专利权人: BASF Aktiengesellschaft
- 当前专利权人: BASF Aktiengesellschaft
- 当前专利权人地址: DEX Rheinland-Pfalz
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A61K38/08 ; A61P35/00 ; C07K7/06 ; C12P19/34
摘要:
Compounds of the present invention include cell growth inhibitors which are peptides of Formula I,A-B-D-E-F-(G).sub.r -(K).sub.s -L (I),and acid salts thereof, wherein A, B, D, E, F, G and K are .alpha.-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a .beta.-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
公开/授权文献
- US5246085A Portable work station 公开/授权日:1993-09-21