发明授权
US06147214A Process and intermediates for the preparation of
4'-trifluoromethyl-biphenyl-2-carboxylic acid
(1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide
失效
制备4'-三氟甲基 - 联苯-2-甲酸（1,2,3,4-四氢 - 异喹啉-6-基） - 酰胺的方法和中间体
- 专利标题： Process and intermediates for the preparation of 4'-trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide
- 专利标题（中）： 制备4'-三氟甲基 - 联苯-2-甲酸（1,2,3,4-四氢 - 异喹啉-6-基） - 酰胺的方法和中间体
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申请号： US403266申请日： 1999-10-15
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公开(公告)号： US06147214A公开(公告)日： 2000-11-14
- 发明人: John Anthony Ragan
- 申请人： John Anthony Ragan
- 申请人地址： NY New York
- 专利权人： Pfizer Inc
- 当前专利权人： Pfizer Inc
- 当前专利权人地址： NY New York
- 主分类号： C07D217/22
- IPC分类号： C07D217/22 ; A61K31/4725 ; A61P3/06 ; A61P9/10 ; C07C233/66 ; C07C233/75 ; C07C233/76 ; C07C233/80 ; C07D217/02 ; C07D217/04
摘要：
An improved process, and intermediates, for the preparation of 4'-trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4-tetrahydro-isoquinoline-6-yl) amide (I), are disclosed. Compound (I) is useful as an inhibitor of microsomal triglyceride transfer protein and/or apolipoprotein B secretion, and which are accordingly useful for the preparation and treatment of atherosclerosis and its clinical sequelae, for lowering serum lipids, and related diseases.
公开/授权文献
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