发明授权
US6150393A Small molecule modulators of non-endogenous, constitutively activated
human serotonin receptors
有权
非内源性，组成型激活的人类5-羟色胺受体的小分子调节剂
- 专利标题： Small molecule modulators of non-endogenous, constitutively activated human serotonin receptors
- 专利标题（中）： 非内源性，组成型激活的人类5-羟色胺受体的小分子调节剂
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申请号： US418721申请日： 1999-10-15
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公开(公告)号： US6150393A公开(公告)日： 2000-11-21
- 发明人: Dominic P. Behan , Derek T. Chalmers , Nigel R. A. Beeley , Richard J. Foster , Robert C. Glen , Michael S. Lawless , Chen W. Liaw , Qian Liu , Frederique Menzaghi , Joseph F. Russo , Julian R. Smith , William J. Thomsen
- 申请人： Dominic P. Behan , Derek T. Chalmers , Nigel R. A. Beeley , Richard J. Foster , Robert C. Glen , Michael S. Lawless , Chen W. Liaw , Qian Liu , Frederique Menzaghi , Joseph F. Russo , Julian R. Smith , William J. Thomsen
- 申请人地址： CA San Diego
- 专利权人： Arena Pharmaceuticals, Inc.
- 当前专利权人： Arena Pharmaceuticals, Inc.
- 当前专利权人地址： CA San Diego
- 主分类号： A61P25/00
- IPC分类号： A61P25/00 ; C07D20060101 ; C07D231/12 ; C07D231/16 ; C07D409/12 ; C07K14/705 ; A61K31/415
摘要：
Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT.sub.2A and human 5-HT.sub.2C receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT.sub.2A receptors. Yet further disclosed is a new class of compounds which act at the 5HT.sub.2A receptors.
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