发明授权
- 专利标题: Process for preparing .beta.-lactam derivatives
- 专利标题(中): 烯丙基β-内酰胺化合物的制备方法
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申请号: US266584申请日: 1999-03-11
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公开(公告)号: US6150519A公开(公告)日: 2000-11-21
- 发明人: Sigeru Torii , Hideo Tanaka , Michio Sasaoka , Yutaka Kameyama , Isao Wada , Yasuhisa Amano
- 申请人: Sigeru Torii , Hideo Tanaka , Michio Sasaoka , Yutaka Kameyama , Isao Wada , Yasuhisa Amano
- 申请人地址: JPX Osaka
- 专利权人: Otsuka Kagaku Kabushiki Kaisha
- 当前专利权人: Otsuka Kagaku Kabushiki Kaisha
- 当前专利权人地址: JPX Osaka
- 优先权: JPX7-79487 19950310; JPX7-79490 19950310; JPXPCT/JP96/00575 19960308
- 主分类号: C07D205/09
- IPC分类号: C07D205/09 ; C07D205/095 ; C07D501/00 ; C07D501/08 ; C07D513/04
摘要:
A process for preparing an allenyl .beta.-lactam compound represented by the formula (4), characterized by reacting the hydroxyl group of a .beta.-lactam compound represented by the formula (1) with a reactive functional group derivative of sulfonic acid represented by the formula (2) to convert the compound of the formula (1) to a .beta.-lactam compound represented by the formula (3), thereafter reacting the resulting .beta.-lactam compound with a basic anion exchange resin of the type having a tertiary organic base fixed to the resin and isolating the resulting allenyl .beta.-lactam compound of the formula (4) from the reaction mixture ##STR1##