发明授权
- 专利标题: Process for iohexol manufacture
- 专利标题(中): 碘海醇生产工艺
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申请号: US312956申请日: 1999-05-17
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公开(公告)号: US6153796A公开(公告)日: 2000-11-28
- 发明人: Dick Malthe-S.o slashed.rensen , Odd Einar Ingvoldstad , Espen Myrbr.ang.ten
- 申请人: Dick Malthe-S.o slashed.rensen , Odd Einar Ingvoldstad , Espen Myrbr.ang.ten
- 申请人地址: NOX Oslo
- 专利权人: Nycomed Imaging AS
- 当前专利权人: Nycomed Imaging AS
- 当前专利权人地址: NOX Oslo
- 优先权: GBX9618056 19960829
- 主分类号: C07C231/08
- IPC分类号: C07C231/08 ; C07C237/46 ; C07C233/05
摘要:
The invention provides a process for the production of iohexol comprising reacting 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodophthalamide with a 2,3-dihydroxypropylating agent, the improvement comprising effecting that said process in the presence of a solvent comprising 2-methoxy-ethanol and, optionally, isopropanol.
公开/授权文献
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