Invention Grant
US6156321A Tissue factor methods and compositions for coagulation and tumor
treatment
失效
用于凝血和肿瘤治疗的组织因子方法和组合物
- Patent Title: Tissue factor methods and compositions for coagulation and tumor treatment
- Patent Title (中): 用于凝血和肿瘤治疗的组织因子方法和组合物
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Application No.: US9822Application Date: 1998-01-20
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Publication No.: US6156321APublication Date: 2000-12-05
- Inventor: Philip E. Thorpe , Steven W. King , Boning Gao
- Applicant: Philip E. Thorpe , Steven W. King , Boning Gao
- Applicant Address: TX Austin
- Assignee: Board Of Regents, The University of Texas System
- Current Assignee: Board Of Regents, The University of Texas System
- Current Assignee Address: TX Austin
- Main IPC: A61K45/00
- IPC: A61K45/00 ; A61K38/00 ; A61K47/48 ; A61P7/02 ; A61P35/00 ; A61K39/395 ; A61K35/16 ; A61K39/00 ; C07K14/00
Abstract:
The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulant-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa (FVIIa) or FVIIa activators.
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