发明授权
US6156335A Preparation with an acrylic-based, adhesive copolymeric matrix for the
transdermal delivery of estradiol
失效
使用丙烯酸基粘合剂共聚物基质制备用于经皮递送雌二醇
- 专利标题： Preparation with an acrylic-based, adhesive copolymeric matrix for the transdermal delivery of estradiol
- 专利标题（中）： 使用丙烯酸基粘合剂共聚物基质制备用于经皮递送雌二醇
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申请号： US244132申请日： 1994-07-15
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公开(公告)号： US6156335A公开(公告)日： 2000-12-05
- 发明人: Luigi Rovati , Lucio Rovati , Francesco Makovec , Gunter Cordes , Wilfried Fischer
- 申请人： Luigi Rovati , Lucio Rovati , Francesco Makovec , Gunter Cordes , Wilfried Fischer
- 申请人地址： ITX Monza
- 专利权人： Rotta Research Laboratorium S.p.A.
- 当前专利权人： Rotta Research Laboratorium S.p.A.
- 当前专利权人地址： ITX Monza
- 优先权： ITXTO91A0907 19911125
- 主分类号： A61K9/70
- IPC分类号： A61K9/70 ; A61K31/565 ; C07J1/00 ; A61F13/02
摘要：
The invention is represented by a transdermal medicated patch for the extended release of 17.beta.-estradiol to the skin. The transdermal patch is formed by an outer covering, a matrix containing from 1% to 5% (w/w) 17.beta.-estradiol, and a protective liner which is removed before use. The matrix is formed of pressure-sensitive adhesive acrylic copolymers, in which the active ingredient is dissolved or dispersed. The acrylic copolymers are obtained by radical copolymerization of 2-ethylhexyl acrylate, methyl acrylate, acrylic acid, vinyl acetate, hydroxyethyl acrylate or a mixture thereof. Optionally quantities of less than 0.5% (w/w) of other substances may be added.
公开/授权文献
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