发明授权
US6162803A Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression
失效
吲哚-3-基 - 环己基胺衍生物用于治疗抑郁症
- 专利标题： Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression
- 专利标题（中）： 吲哚-3-基 - 环己基胺衍生物用于治疗抑郁症
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申请号： US287676申请日： 1999-04-07
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公开(公告)号： US6162803A公开(公告)日： 2000-12-19
- 发明人: Richard E. Mewshaw , Ping Zhou
- 申请人： Richard E. Mewshaw , Ping Zhou
- 申请人地址： NJ Madison
- 专利权人： American Home Products Corp.
- 当前专利权人： American Home Products Corp.
- 当前专利权人地址： NJ Madison
- 主分类号： C07D413/12
- IPC分类号： C07D413/12 ; A61K31/536 ; A61K31/4985 ; C07D215/12 ; C07D241/38 ; C07D413/08
摘要：
Compounds effective in treating disorders of the serotonin-affected neurological symptoms are provided, such compounds having the following formula: ##STR1## wherein: R.sub.1 and R.sub.5 are each, independently, hydrogen, halogen, lower alkoxy, lower alkyl, cyano, or trifluoromethyl;R.sub.2 and R.sub.4 are each, independently, hydrogen, lower alkyl, phenyl, or substituted phenyl;R.sub.3 is hydrogen or lower alkyl; andX and Y are each, independently, O, NR.sub.6, or CH.sub.2, whereinR.sub.6 is hydrogen, lower alkyl, phenyl, or substituted phenyl; or pharmaceutically acceptable salts thereof.