发明授权
- 专利标题: Subsaturated nicotine transdermal therapeutic system
- 专利标题(中): 亚饱和尼古丁透皮治疗系统
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申请号: US662857申请日: 1991-03-01
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公开(公告)号: US6165497A公开(公告)日: 2000-12-26
- 发明人: James L. Osborne , Melinda Nelson , David J. Enscore , Su Il Yum , Robert M. Gale
- 申请人: James L. Osborne , Melinda Nelson , David J. Enscore , Su Il Yum , Robert M. Gale
- 申请人地址: CA Mountain View
- 专利权人: ALZA Corporation
- 当前专利权人: ALZA Corporation
- 当前专利权人地址: CA Mountain View
- 主分类号: A61K9/70
- IPC分类号: A61K9/70 ; A61K31/465 ; A61F13/02 ; A61F13/00
摘要:
Rate controlled transdermal nicotine delivery systems are disclosed which utilize an in-line adhesive to maintain the systems on the skin. The initial equilibrated concentration of nicotine in the nicotine reservoir and the adhesive is below saturation, preferably at a thermodynamic activity no greater than 0.50, and the reservoir comprises the nicotine dissolved in a polymer with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of nicotine in the reservoir is sufficient to prevent the activity of the nicotine in the reservoir from decreasing by more than about 75% and preferably no more than about 25% during the predetermined period of administration; and the thicknesses of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and, preferably at least 75% initial equilibrated nicotine loading is in the reservoir layer.
公开/授权文献
- US4036691A Nuclear fuel element 公开/授权日:1977-07-19