发明授权
- 专利标题: 2-carbonylthiazole derivatives and use of the same
- 专利标题(中): 2-羰基噻唑衍生物及其用途
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申请号: US269021申请日: 1999-11-05
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公开(公告)号: US6166033A公开(公告)日: 2000-12-26
- 发明人: Atsuro Nakazato , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Masanori Yoshida
- 申请人: Atsuro Nakazato , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Masanori Yoshida
- 申请人地址: JPX JPX
- 专利权人: Taisho Pharmaceutical Co., Ltd.,Nihon Nohyaku Co., Ltd.
- 当前专利权人: Taisho Pharmaceutical Co., Ltd.,Nihon Nohyaku Co., Ltd.
- 当前专利权人地址: JPX JPX
- 优先权: JPX8-249415 19960920
- 主分类号: A61K31/425
- IPC分类号: A61K31/425 ; C07D417/06 ; A61K31/4535 ; A61K31/496 ; C07D211/70 ; C07D401/14 ; C07D413/06
摘要:
This invention provides a 2-carbonylthiazole derivative represented by formula (I): ##STR1## wherein each of Ar.sup.1 and Ar.sup.2 represents a phenyl group or a substituted phenyl group; R.sup.1 represents an alkoxy group having 1 to 5 carbon atoms, a hydroxyl group or an amino group; Y.sup.1 --Y.sup.2 represents CH--CO or C.dbd.CR.sup.2, wherein R.sup.2 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms; and n is an integer of from 1 to 4, or a pharmaceutically acceptable salt thereof. The disclosed compounds are useful as drugs for preventing and treating dopamine D receptor-related morbid states such as schizophrenia and problematic behavior caused by cerebrovascular accidents and senile dementia and do not induce extrapyramidal disorders as side effects.
公开/授权文献
- US5622905A Silicon nitride based sintered body 公开/授权日:1997-04-22
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