发明授权
- 专利标题： ARF-p19, a novel regulator of the mammalian cell cycle
- 专利标题（中）： ARF-p19，哺乳动物细胞周期的新型调节剂
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申请号： US09247154申请日： 1999-02-09
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公开(公告)号： US06172194B2公开(公告)日： 2001-01-09
- 发明人: Charles J. Sherr , Dawn E. Quelle
- 申请人： Charles J. Sherr , Dawn E. Quelle
- 主分类号： C07K1400
- IPC分类号： C07K1400
摘要：
The INK4A (MTS1, CDKN2) gene encodes a specific inhibitor (InK4a-p16) of the cyclin D-dependent kinases CDK4 and CDK6. InK4a-p16 can block these kinase from phosphorylating the retinoblastoma protein (pRb), preventing exit from the G1 phase of the cell cycle. Deletions and mutations involving the gene encoding InK4a-p16, INK4A, occur frequently in cancer cells, implying that INK4a-p16, like pRb, suppresses tumor formulation. However, a completely unrelated protein (ARF-p19) arises in major part from an alternative reading frame of the mouse INK4A gene. Expression of an ARF-p19 cDNA (SEQ ID NO:1) in rodent fibroblasts induces both G1 and G2 phase arrest.
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