The invention relates to a novel process for producing novel extracts of Ginkgo biloba leaves. The invention further relates to a process which produces novel extracts of Ginkgo biloba with an increased amount of one of the major lactones and having an improved biological activity. Further, the disclosed process allows for a controlled method to produce a desired ratio of flavone glycosides to lactones in the end product. The invention also discloses new extracts from Ginkgo biloba, particularly for oral application.