发明授权
US06174888B1 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones
失效
2-氨基-7-（1-取代-2-羟乙基）-3,5-二氢吡咯并[3,2-D]嘧啶-4-酮
![2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones](/docs/US/2001-01-16/US06174888B1/abs.jpg.600x600.jpg)
- 专利标题： 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones
- 专利标题（中）： 2-氨基-7-（1-取代-2-羟乙基）-3,5-二氢吡咯并[3,2-D]嘧啶-4-酮
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申请号： US09085791申请日： 1998-05-28
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公开(公告)号： US06174888B1公开(公告)日： 2001-01-16
- 发明人: Leslie W. McQuire , Benjamin B. Mugrage , John H. van Duzer
- 申请人： Leslie W. McQuire , Benjamin B. Mugrage , John H. van Duzer
- 主分类号： C07D48704
- IPC分类号： C07D48704
![2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones](/abs-image/US/2001/01/16/US06174888B1/abs.jpg.150x150.jpg)
摘要：
The invention relates to the 2-amino-7-(1-substituted-2-hydroxyethyl)-3, 5-dihydro-pyrrolo[3,2-d] pyrimidin-4-ones of formula I and tautomers thereof, wherein Ar represents biaryl, carbocyclic or heterocyclic aryl; pharmaceutically acceptable prodrug ester derivatives; and pharmaceutically acceptable salts thereof, which are particularly useful as potent purine nucleoside phosphorylase (PNP) inhibitors.