发明授权
US06175057B1 Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy
失效
阿尔茨海默病和脑淀粉样血管病的转基因小鼠模型
- 专利标题： Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy
- 专利标题（中）： 阿尔茨海默病和脑淀粉样血管病的转基因小鼠模型
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申请号： US08947295申请日： 1997-10-08
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公开(公告)号： US06175057B1公开(公告)日： 2001-01-16
- 发明人: Lennart Mucke , Tony Wyss-Coray , Eliezer Masliah
- 申请人： Lennart Mucke , Tony Wyss-Coray , Eliezer Masliah
- 主分类号： A01K6700
- IPC分类号： A01K6700
摘要：
The present invention features non-human transgenic animal models for Alzheimer's disease (AD) and CAA, wherein the transgenic animal is characterized by 1) overexpression of bioactive transforming growth factor-&bgr;1 (TGF-&bgr;1) or 2) both overexpression of bioactive TGF-&bgr;1 and expression of a human amyloid &bgr; precursor protein (APP) gene product. The transgenic animals may be either homozygous or heterozygous for these alterations. Bigenic animals are further characterized by development of AD-associated and/or CAA-associated pathology within about two to three months of age.