发明授权
- 专利标题： Bacteriohopanetetrol and related compounds useful for modulation of lipoxygenase activity and anti-inflammatory applications
- 专利标题（中）： 用于调节脂氧合酶活性和抗炎应用的细菌素乙内酯和相关化合物
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申请号： US08844631申请日： 1997-04-21
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公开(公告)号： US06177415B1公开(公告)日： 2001-01-23
- 发明人: Robert A. Moreau , Kevin B. Hicks
- 申请人： Robert A. Moreau , Kevin B. Hicks
- 主分类号： A61K3156
- IPC分类号： A61K3156
摘要：
The arachidonic acid-metabolizing hopanoid tetrahydroxybacteriohopane (THBH) was isolated from Zymomonas mobilis and was found to inhibit soybean 15-lipoxygenase, and thus lipoxin biosynthesis, with an IC50 of about 10 &mgr;M. The activities of two other arachidonic acid-metabolizing enzymes, human 5-lipoxygenase (involved in prostaglandin biosynthesis) and prostaglandin H synthase, were unaffected by THBH. Subsequent studies showed that THBH was effective as an anti-inflammatory agent in topical applications.