发明授权
- 专利标题： Method for the fermentative production of D-pantothenic acid using strains of the family enterobacteriaceae
- 专利标题（中）： 使用肠杆菌科菌株发酵生产D-泛酸的方法
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申请号： US09318739申请日： 1999-05-26
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公开(公告)号： US06184006B2公开(公告)日： 2001-02-06
- 发明人: Mechthild Rieping , Georg Thierbach , Walter Pfefferle , Nicole Dusch , Jorn Kalinowski , Alfred Puhler
- 申请人： Mechthild Rieping , Georg Thierbach , Walter Pfefferle , Nicole Dusch , Jorn Kalinowski , Alfred Puhler
- 优先权： DE19855314 19981201
- 主分类号： C12P1300
- IPC分类号： C12P1300
摘要：
A method for the production of D-pantothenic acid by the fermentation of microorganisms of the family Enterobacteriacae producing D-pantothenic acid which is characterized in that strains are used which a) Contain the plasmid pFV31 and/or pFV202 and that b) A panD gene and optionally other nucleotide sequences coding for aspartate-1-decarboxylase are enhanced, especially overexpressed in these microorganisms, c) The pantothenic acid is enriched in the medium or in the cells of the microorganisms and d) The pantothenic acid formed is isolated.