Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof

发明授权

US06184377B2 Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof 失效

标题翻译：含有N-氨基和N-羟基 - 喹唑啉酮的组合物及其制备方法

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专利标题： Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof
专利标题（中）： 含有N-氨基和N-羟基 - 喹唑啉酮的组合物及其制备方法
申请号： US08990855

申请日： 1997-12-15
公开(公告)号： US06184377B2

公开(公告)日： 2001-02-06
发明人: Yun Gao
申请人： Yun Gao
主分类号： C07D23992
IPC分类号： C07D23992

Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof

摘要：

The present invention is directed to certain N-amino- and N-hydroxy-quinazolinone compounds and synthetic methods for synthesis thereof, which compounds may find use in combinatorial libraries. More specifically, the invention is directed to the synthesis of 3-hydroxy- and 3-amino-4(1H)-quinazolinones via the reaction of an appropriate 2-aminobenzamide compound with a carboxylic acid or acyl halide at ambient temperature performed on a solid support or in solution.

摘要（中）：

本发明涉及某些N-氨基 - 和N-羟基 - 喹唑啉酮化合物及其合成方法，该化合物可用于组合文库。更具体地，本发明涉及通过适当的2-氨基苯甲酰胺化合物与羧酸或酰基卤在环境温度下对固体进行的反应合成3-羟基 - 和3-氨基-4（1H） - 喹唑啉酮支持或解决方案。

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