发明授权
- 专利标题： Simple process for producing high quality captopril
- 专利标题（中）： 生产高品质卡托普利的简单过程
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申请号： US09077747申请日： 1998-08-03
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公开(公告)号： US06187932B1公开(公告)日： 2001-02-13
- 发明人: Koichi Kinoshita , Fumihiko Kano , Takahiro Okubo , Yasuyoshi Ueda
- 申请人： Koichi Kinoshita , Fumihiko Kano , Takahiro Okubo , Yasuyoshi Ueda
- 优先权： JP8-289340 19961011
- 主分类号： C07D20712
- IPC分类号： C07D20712
摘要：
A process for producing captopril of the following formula (1) comprising subjecting a substrate compound of the following general formula (2) to a hydrolysis reaction in aqueous medium to remove the RCO group and isolating the product compound, said hydrolysis reaction in aqueous medium being conducted in the presence of a strong acid at pH not over 1 and a reaction temperature not below 40° C.
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