发明授权
US06191130B1 Cyclohexane derivatives difunctionalised in 1,4 as ligands of 5T H1A receptors
有权
环己烷衍生物在1,4中作为5T H1A受体的配体双功能化
- 专利标题: Cyclohexane derivatives difunctionalised in 1,4 as ligands of 5T H1A receptors
- 专利标题(中): 环己烷衍生物在1,4中作为5T H1A受体的配体双功能化
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申请号: US09529783申请日: 2000-04-14
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公开(公告)号: US06191130B1公开(公告)日: 2001-02-20
- 发明人: Jean-François Patoiseau , Elisabeth Dupont-Passelaigue , Wouter Koek
- 申请人: Jean-François Patoiseau , Elisabeth Dupont-Passelaigue , Wouter Koek
- 优先权: FR9712954 19971016
- 主分类号: C07D25306
- IPC分类号: C07D25306
摘要:
The invention concerns novel cyclohexane derivatives difunctionalised in 1.4 of general formula (1) in which A represents a group such as (IIa) in which Ar itself represents an aromatic structure such as phenyl or pyrimidinyl optionally substituted by one or several groups such as C1-C3 alkyl, C1-C3 alkoxy, trifluoromethyl or halogen (IIb); B represents a heterocyclic group such as: 3,5-dioxo-(2H,4H)-1,2,4 triazine substituted in position 2 (IIIa); 3-oxo-(2H)-1,2,4 triazine substituted in position 5 (IIIb); 3,5-dioxo-6-amino-(2H,4H)-1,2,4-triazine (IIIc) in which R represents a C1-C3 alkyl group. The invention also concerns the salts of compounds of general formula I with pharmaceutically acceptable acids. It also concerns the various “cis” and “trans” isomers and the various enantiomers with asymmetric carbons.