发明授权
- 专利标题: Production process and intermediate of tetrazole compound
- 专利标题(中): 四唑化合物的生产工艺和中间体
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申请号: US09176198申请日: 1998-10-21
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公开(公告)号: US06191289B1公开(公告)日: 2001-02-20
- 发明人: Hideki Ushio , Takayuki Higashii , Masayoshi Minai , Akihiko Nakamura
- 申请人: Hideki Ushio , Takayuki Higashii , Masayoshi Minai , Akihiko Nakamura
- 优先权: JP5-100832 19940516; JP6-069204 19950328
- 主分类号: C07D25704
- IPC分类号: C07D25704
摘要:
There are disclosed an industrially favorable process for producing a tetrazole compound of general formula (1): characterized in that a nitrile of general formula (2): R1CN (2) is reacted with hydrazine or a salt thereof in the presence of a catalyst, followed by reaction with a nitrous acid compound of general formula (3): ANO2 (3) or a nitrile of general formula (2) is reacted with hydrogen sulfide, followed by reaction with an alkyl halide of general formula (4): R4J (4) with hydrazine or a salt thereof, and then with a nitrous acid compound of general formula (3); and an intermediate of general formula (5): R1C(═R5)R6 (5) which is useful for the production of the tetrazole compound (in which R1 to R6, A and J in the above formulas are as defined in the specification).
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