发明授权
US06194405B1 Method of using substituted tetracyclic tetrahydrofuran derivatives
有权
使用取代四环四氢呋喃衍生物的方法
- 专利标题: Method of using substituted tetracyclic tetrahydrofuran derivatives
- 专利标题(中): 使用取代四环四氢呋喃衍生物的方法
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申请号: US09533625申请日: 2000-03-22
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公开(公告)号: US06194405B1公开(公告)日: 2001-02-27
- 发明人: Pilar Gil-Lopetegui , Francisco Javier Fernández-Gadea , Theo Frans Meert
- 申请人: Pilar Gil-Lopetegui , Francisco Javier Fernández-Gadea , Theo Frans Meert
- 优先权: EP96200990 19960412
- 主分类号: A01N4346
- IPC分类号: A01N4346
摘要:
This invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and q are zero to 4; r is zero to 5; R1 and R2 each independently are hydrogen; optionally substituted C1-6alkyl; C1-6alkylcarbonyl; halomethylcarbonyl; or R1 and R2 taken together with the nitrogen atom to which they are attached may form a morpholinyl ring or an optionally substituted heterocycle; each R3 and R4 independently are halo, cyano, hydroxy, halomethyl, halomethoxy, carboxyl, nitro, amino, mono- or di(C1-6alkyl)amino, C1-6alkylcarbonylamino, aminosulfonyl, mono- or di(C1-6alkyl)aminosulfonyl, C1-6alkyl, C1-6alkyloxy, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl; each R5 independently is C1-6alkyl, cyano or halomethyl; X is CR6R7, NR8, O, S, S(═O) or S(═O)2; aryl is optionally substituted phenyl; provided that the compound is other than (±)-3,3a,8,12b-tetrahydro-N-methyl-2H-dibenzo[3,4:6,7]-cyclohepta[1,2-b]-furan-2-methanamine oxalic acid. The compounds of formula (I) may be used as therapeutic agents in the treatment or the prevention of CNS disorders, cardiovascular disorders or gastrointestinal disorders.
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