发明授权
- 专利标题: Non-peptide bombesin receptor antagonists
- 专利标题(中): 非肽铃蟾肽受体拮抗剂
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申请号: US09230933申请日: 1999-02-03
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公开(公告)号: US06194437B1公开(公告)日: 2001-02-27
- 发明人: David Christopher Horwell , Martyn Clive Pritchard
- 申请人: David Christopher Horwell , Martyn Clive Pritchard
- 主分类号: C07D40112
- IPC分类号: C07D40112
摘要:
The compounds of the instant invention are novel compounds of Formula I or a pharmaceutically acceptable salt thereof wherein Ar is phenyl or pyridyl unsubstituted or substituted. Ar1 can be independently selected from Ar and can also include pyridyl-N-oxide, indolyl, imidazole, and pyridyl; R3 can be independently selected from Ar or is hydrogen, hydroxy, NMe2, N-methyl-pyrrole, imidazole, tetrazole, thiazole (a), (b), (c), or (d), wherein Ar2 is phenyl or pyridyl. The instant compounds antagonize the bombesin receptors in mammals and are therefore effective in treating and/or preventing depression, psychoses, seasonal affective disorders, cancer, feeding disorders, gastrointestinal disorders, inflammatory bowel disease, sleep disorders, and memory impairment.
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