发明授权
US06197761B1 17&bgr;-2-oxo-tetrahydrofuranyl)-carbothioic acid ester, -carboxylic acid ester and -carboxylic acid amide androstane derivatives
失效
17β-2-氧代 - 四氢呋喃基） - 硫代羧酸酯，羧酸酯和羧酸酰胺雄甾烷衍生物
- 专利标题： 17&bgr;-2-oxo-tetrahydrofuranyl)-carbothioic acid ester, -carboxylic acid ester and -carboxylic acid amide androstane derivatives
- 专利标题（中）： 17β-2-氧代 - 四氢呋喃基） - 硫代羧酸酯，羧酸酯和羧酸酰胺雄甾烷衍生物
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申请号： US09091748申请日： 1998-06-24
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公开(公告)号： US06197761B1公开(公告)日： 2001-03-06
- 发明人: Keith Biggadike , Panayiotis Alexandrou Procopiou
- 申请人： Keith Biggadike , Panayiotis Alexandrou Procopiou
- 优先权： GB9526651 19951229; GB9613121 19960621
- 主分类号： A61K3158
- IPC分类号： A61K3158
摘要：
Compounds of the androstane series are described having general formula and solvates thereof, in which R1 represents O, S or NH; R2 individually represents OC(═O)C1-6 alkyl; R3 individually represents hydrogen, methyl (which may be in either the &agr; or &bgr; configuration) or methylene; or R2 and R3 together represent where R6 and R7 are the same or different and each represents hydrogen or C1-6 alkyl; R4 and R5 are the same or different and each represents hydrogen or halogen and represents a single or a double bond. These compounds and their solvates have use in medicine as anti-inflammatory or anti-allergic agents.
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