发明授权
- 专利标题: Triazolones as apolipoprotein-B synthesis inhibitors
- 专利标题(中): 新型三唑酮作为载脂蛋白-B合成抑制剂
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申请号: US09251989申请日: 1999-02-17
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公开(公告)号: US06197972B1公开(公告)日: 2001-03-06
- 发明人: Jan Heeres , Leo Jacobus Jozef Backx , Paul August Clement Luyts
- 申请人: Jan Heeres , Leo Jacobus Jozef Backx , Paul August Clement Luyts
- 优先权: EP95201010 19950420
- 主分类号: C07D40506
- IPC分类号: C07D40506
摘要:
The present invention concerns novel compounds of formula (I). wherein R1 is C1-10alkyl, C3-7cycloalkyl or C1-6alkyl substituted with C3-7cycloalkyl; R2 is hydrogen or C1-6alkyl; Alk represents C1-3alkanediyl; —A— represents a bivalent radical of formula —CH═CH—N═CH— (a), —N═CH—N═CH— (b), —CH═N—N═CH— (c), —CH═CH—CH═N— (d); in said bivalent radicals a hydrogen atom may be replaced by C1-6alkyl; and Ar is unsubstituted phenyl; phenyl substituted with up to two substituents selected from halo, C1-6alkyl or C1—6alkyloxy; unsubstituted naphthyl; or naphthyl substituted with up to two substituents selected from halo, C1-6alkyl or C1-6alkyloxy; the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts thereof. The present invention further comprises the pharmaceutical compositions comprising compounds of formula (I), the preparation thereof as well as the use as a medicine in the treatment of hyperlipidemia.