发明授权
- 专利标题: Process for preparing optically active carnitine ester
- 专利标题(中): 制备光学活性肉碱酯的方法
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申请号: US08139861申请日: 1993-10-22
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公开(公告)号: US06197996B1公开(公告)日: 2001-03-06
- 发明人: Takanao Taketomi , Toshiaki Sakaguchi , Hidenori Kumobayashi
- 申请人: Takanao Taketomi , Toshiaki Sakaguchi , Hidenori Kumobayashi
- 优先权: JP63-324651 19881222
- 主分类号: C07C22900
- IPC分类号: C07C22900
摘要:
A process for preparing an optically active carnitine ester represented by formula (I): wherein R represents a lower alkyl group; and X represents a halogen atom, is disclosed, comprises asymmetrically hydrogenating a &ggr;-trimethylammonium-3-oxobutanoic ester halide represented by formula (II): wherein R and X are as defined above, in the presence of a ruthenium-optically active phosphine complex as a catalyst. An optically active carnitine ester of any desired isomerism can be obtained through simple operation in high yield at high optical purity. The substrate used is easily available.