A composition showing an improved bioavailability rate of pantothenic acid derivatives represented by the following general formula and improved storage stability and being applicable as drugs over an enlarged range: wherein R1 and R2 are the same or different and each represents a hydrogen atom or a hydroxyl-protective group; R3 represents a saturated or unsaturated, linear, branched or cyclic C5-25 monovalent aliphatic hydrocarbon group optionally substituted by an aromatic group, or an amino group represented by the formula —N(R4)R5 (wherein R4 represents a saturated or unsaturated, linear, branched or cyclic C5-25 monovalent aliphatic hydrocarbon group; and R5 represents a hydrogen atom or a saturated or unsaturated, linear, branched or cyclic monovalent aliphatic hydrocarbon group optionally substituted by an aromatic group); A represents a saturated or unsaturated, linear, branched or cyclic C2-16 divalent aliphatic hydrocarbon group, divalent aromatic hydrocarbon group or divalent heteroaryl group optionally substituted by an aromatic group; one of X and Y represents an amino group represented by the formula —N(R6)— while the other represents —O—, —S— or an amino group represented by the formula —N(R7)— (wherein R6 and R7 represent each a hydrogen atom or a lower alkyl group); and n is an integer of from 1 to 4. The pantothenic acid derivative represented by the above general formula (I) is dissolved in a neutral or alcoholic ester and a nonionic surfactant is added thereto to give the absorption-enhancing composition.