发明授权
- 专利标题： DNA encoding a cytokine
- 专利标题（中）： 编码细胞因子的DNA
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申请号： US08792013申请日： 1997-01-31
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公开(公告)号： US06204021B1公开(公告)日： 2001-03-20
- 发明人: Olga Bandman , Phillip R. Hawkins , Lynn E. Murry , Surya K. Goli
- 申请人： Olga Bandman , Phillip R. Hawkins , Lynn E. Murry , Surya K. Goli
- 主分类号： C12N1500
- IPC分类号： C12N1500
摘要：
The present invention provides novel human cytokines (designated individually as NHC-1 and NHC-2, and collectively as NHC) and polynucleotides which identify and encode NHC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHC and a method for producing NHC. The invention also provides for use of NHC and agonists, antibodies, or antagonists specifically binding NHC, in the prevention and treatment of diseases associated with expression of NHC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHC for the treatment of diseases associated with the expression of NHC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHC.
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