发明授权
- 专利标题: Modified PE40 toxin fusion proteins
- 专利标题(中): 改良的PE40毒素融合蛋白
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申请号: US08798447申请日: 1997-02-10
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公开(公告)号: US06207798B1公开(公告)日: 2001-03-27
- 发明人: Allen I. Oliff , Gwynneth M. Edwards , Deborah D. Jones
- 申请人: Allen I. Oliff , Gwynneth M. Edwards , Deborah D. Jones
- 主分类号: C07K1421
- IPC分类号: C07K1421
摘要:
We have modified PE40 toxin by removing at least two of its four cysteine amino acid residues and have formed hybrid molecules containing modified PE40 linked to a cell recognition protein that can be an antibody, a growth factor, a hormone, a lymphokine, or another polypeptide cell recognition protein for which a specific cellular receptor exists whereby the modified PE40 toxin is directed to cell types having receptors for the cell recognition protein linked to the modified PE40.