发明授权
- 专利标题: Indolin-2-one derivatives
- 专利标题(中): 二氢吲哚-2-酮衍生物
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申请号: US09182490申请日: 1998-10-30
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公开(公告)号: US06207836B1公开(公告)日: 2001-03-27
- 发明人: Toru Esaki , Takashi Emura , Eiichi Hoshino
- 申请人: Toru Esaki , Takashi Emura , Eiichi Hoshino
- 优先权: JP5-67297 19930217; JP5-167262 19930531
- 主分类号: C07D40112
- IPC分类号: C07D40112
摘要:
A compound represented by formula (I): wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, —OR5, —SR5 or —NR6R7 (wherein R5, R6, and R7 each represent a lower alkyl group, etc.); X and Y each represent —CH2—, —NH— or —O—; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed. The compound of the present invention exhibits selective antagonism against gastrin receptors without causing side effects attributed to CCK-A receptor antagonism and is useful for the treatment and prevention of peptic ulcers, gastritis, reflux esophagitis, and Zollinger-Ellison syndrome, and for the treatment of neoplasm originating in the gastrointestinal system.