发明授权
- 专利标题: Process for asymmetric hydrogenation
- 专利标题(中): 不对称氢化方法
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申请号: US09526976申请日: 2000-03-14
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公开(公告)号: US06211386B1公开(公告)日: 2001-04-03
- 发明人: Mark J. Burk , Nicholas B. Johnson , Bradley D. Hewitt
- 申请人: Mark J. Burk , Nicholas B. Johnson , Bradley D. Hewitt
- 主分类号: C07D30930
- IPC分类号: C07D30930
摘要:
The present invention is a process for the preparation of a compound of the formula: where R3, R4 and n are defined in the specification which comprises hydrogenating a compound of the formula: the E-geometrical isomer thereof or a mixture of the Z- and E-isomers in the presence of catalyst containing Rh, a chiral ligand with at least one phosphorous atom where the hydrogenation is conducted in the presence of a base.
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