发明授权
- 专利标题: Process for the preparation of prostaglandin precursors
- 专利标题(中): 制备前列腺素前体的方法
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申请号: US09548076申请日: 2000-04-12
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公开(公告)号: US06214611B1公开(公告)日: 2001-04-10
- 发明人: Martin Edward Fox , Julian Simon Parratt
- 申请人: Martin Edward Fox , Julian Simon Parratt
- 优先权: GB9908327 19990412
- 主分类号: C12P722
- IPC分类号: C12P722
摘要:
A propargylic alcohol, enriched in the (R)-enantiomer, has the formula wherein R is C1-4 alkoxy, halogen, or C1-4 alkyl optionally substituted by OH or halogen. This is prepared by the steps of: (a) enantioselective (R)-esterification of the racemic alcohol using any acyl donor and a first enzyme; (b) removal of the untreated (S)-alcohol; and (c) enantioselective hydrolysis of the (R)-ester, using a second enzyme.
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