发明授权
US06214794B1 Method of using hedgehog polypeptides to regulate neuronal cell growth
失效
使用刺猬蛋白多肽调节神经细胞生长的方法
- 专利标题： Method of using hedgehog polypeptides to regulate neuronal cell growth
- 专利标题（中）： 使用刺猬蛋白多肽调节神经细胞生长的方法
-
申请号： US08729743申请日： 1996-10-07
-
公开(公告)号： US06214794B1公开(公告)日： 2001-04-10
- 发明人: Philip A. Beachy , Randall T. Moon , Jeffrey A. Porter
- 申请人： Philip A. Beachy , Randall T. Moon , Jeffrey A. Porter
- 主分类号： C07K14475
- IPC分类号： C07K14475
摘要：
The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a Gly↓Cys Phe site recognized by the autoproteolytic domain in the native protein. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. Also provided are methods of use of the N and C fragments.
信息查询
