发明授权
US06214842B1 Amino-thiazolidinediones useful in the treatment of insulin resistance and hyperglycemia 失效
用于治疗胰岛素抵抗和高血糖症的氨基 - 噻唑烷二酮类

  • 专利标题: Amino-thiazolidinediones useful in the treatment of insulin resistance and hyperglycemia
  • 专利标题(中): 用于治疗胰岛素抵抗和高血糖症的氨基 - 噻唑烷二酮类
  • 申请号: US09568832
    申请日: 2000-05-11
  • 公开(公告)号: US06214842B1
    公开(公告)日: 2001-04-10
  • 发明人: Michael S. MalamasIwan Gunawan
  • 申请人: Michael S. MalamasIwan Gunawan
  • 主分类号: A61K3156
  • IPC分类号: A61K3156
Amino-thiazolidinediones useful in the treatment of insulin resistance and hyperglycemia
摘要:
This invention provides compounds of Formula I having the structure wherein: R is hydrogen or alkyl of 1-6 carbon atoms; A is R1, R2, R3 are each, independently, hydrogen, alkoxy of 1-6 carbon atoms, thioalkyl of 1-6 carbon atoms, trifluoromethyl, R4 is hydrogen, alkyl of 1-6 carbon atoms, halogen, or alkoxy of 1-6 carbon atoms; R5 is phenyl, naphthyl, thienyl, furyl, wherein R5 may be optionally mono-, di-, or tri-substituted with a sustituent selected from the group consisting of alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, trifluoromethyl, halogen, alkoxycarbonyl of 2-7 carbon atoms, alkylamino of 1-6 carbon atoms, and dialkylamino in which each of the alkyl groups is of 1-6 carbon atoms, nitro, cyano, —CO2H, alkylcarbonyloxy of 2-7 carbon atoms, and alkylcarbonyl of 2-7 carbon atoms; m=1-4; n=1-4; and X=O, S, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
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