发明授权
US06218405B1 Heteroarylsulfonamide derivatives and pharmaceutical compositions containing them
有权
杂芳基磺酰胺衍生物和含有它们的药物组合物
- 专利标题: Heteroarylsulfonamide derivatives and pharmaceutical compositions containing them
- 专利标题(中): 杂芳基磺酰胺衍生物和含有它们的药物组合物
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申请号: US09331064申请日: 1999-06-16
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公开(公告)号: US06218405B1公开(公告)日: 2001-04-17
- 发明人: Alan Martin Birch , Paul Anthony Bradley
- 申请人: Alan Martin Birch , Paul Anthony Bradley
- 优先权: GB9627005 19961227
- 主分类号: A61K31445
- IPC分类号: A61K31445
摘要:
Compounds of formula (I) and pharmaceutically acceptable salts thereof in which A is methylene or —O—; B is methylene or —O—; G1—G2—G3 form a heteroaromatic or heteroaliphatic chain; g is 0, 1 or 2; U is an alkylene chain optionally substituted by one or more alkyl; Q represents a divalent group containing nitrogen atoms; and T is an optionally substituted aryl or heteroaryl group, have utility in the treatment of central nervous system disorders, for example depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, Parkinson's disease, obesity, hypertension, Tourette's syndrome, sexual dysfunction, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, senile dementia, obsessive-compulsive behavior, panic attacks, social phobias, eating disorders and anorexia, cardiovascular and cerebrovascular disorders, non-insulin dependent diabetes mellitus, hyperglycaemia, constipation, arrhythmia, disorders of the neuroendrocrine system, stress, and spasticity.
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