发明授权
US06218519B1 Compounds and methods for the selective treatment of cancer and bacterial infections
失效
用于选择性治疗癌症和细菌感染的化合物和方法
- 专利标题： Compounds and methods for the selective treatment of cancer and bacterial infections
- 专利标题（中）： 用于选择性治疗癌症和细菌感染的化合物和方法
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申请号： US08635243申请日： 1996-04-12
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公开(公告)号： US06218519B1公开(公告)日： 2001-04-17
- 发明人: John H. Kenten , David M. Simpson
- 申请人： John H. Kenten , David M. Simpson
- 主分类号： C07H1524
- IPC分类号： C07H1524
摘要：
The present invention relates to compounds containing an anthracyclinone group such as doxorubicin, daunorubicin or a derivative thereof. The compounds of the invention also contain ester, glycoside or glucuronide structures which are hydrolyzed by the corresponding esterase, glycosidase or glucuronidase. These compounds possess potent cytotoxic activity which is developed after the hydrolysis of the ester or glycoside group of the compound and are effective in the inhibition of tumor cells and bacterial growth after activation.
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