发明授权
US06218547B1 1-phenyl-benzimidazole compounds and their use as GABA-a receptor modulators
失效
1-苯基 - 苯并咪唑化合物及其作为GABA-a受体调节剂的用途
- 专利标题: 1-phenyl-benzimidazole compounds and their use as GABA-a receptor modulators
- 专利标题(中): 1-苯基 - 苯并咪唑化合物及其作为GABA-a受体调节剂的用途
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申请号: US09269643申请日: 1999-03-31
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公开(公告)号: US06218547B1公开(公告)日: 2001-04-17
- 发明人: Lene Teuber , Frank Watjen
- 申请人: Lene Teuber , Frank Watjen
- 优先权: DK1157/96 19961021
- 主分类号: C07D23502
- IPC分类号: C07D23502
摘要:
The present invention relates to novel benzimidazole compounds, represented by general formula (I) in which o is 0, 1, 2 or 3; R1 represents an alkyl group, a phenyl group, or a monocyclic heterocyclic group, which groups may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkyl-alkyl, alkoxy, halogen, trifluoromethyl, cyano, amino and nitro; or R1 represents a cyano group or a group of the formula -alkyl-CO2R2, alkenyl-CO2R2, —CO—R2, —CO2(CH2)mR2, or —C(R3)═N—OR2, R11 represents a group of formula —CO2—R9, or R11 represents a group of general formula (II) in which n is 0, 1, 2 or 3; or R11 may represent a group of general formula (III), in which n is 0, 1, 2 or 3; the novel compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, such as for example anxiety, sleep disorders, anaestesia, memory disorders, and epilepsia or other convulsive disorders.
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