发明授权
US06218568B1 Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
有权
制备2-（2-氨基-1,6-二氢-6-氧代 - 嘌呤-9-基）甲氧基-1,3-丙二醇衍生物的方法
- 专利标题： Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
- 专利标题（中）： 制备2-（2-氨基-1,6-二氢-6-氧代 - 嘌呤-9-基）甲氧基-1,3-丙二醇衍生物的方法
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申请号： US09497538申请日： 2000-02-03
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公开(公告)号： US06218568B1公开(公告)日： 2001-04-17
- 发明人: Charles A. Dvorak , Douglas L. Wren , Lawrence E. Fisher , Steven D. Axt , Eric R. Humphreys , Humberto B. Arzeno , Colin C. Beard , Sam Linh Nguyen , Yeun-Kwei Han , Christopher R. Roberts , Jan P. Lund , Paul R. Fatheree
- 申请人： Charles A. Dvorak , Douglas L. Wren , Lawrence E. Fisher , Steven D. Axt , Eric R. Humphreys , Humberto B. Arzeno , Colin C. Beard , Sam Linh Nguyen , Yeun-Kwei Han , Christopher R. Roberts , Jan P. Lund , Paul R. Fatheree
- 主分类号： C07C67743
- IPC分类号： C07C67743
摘要：
Process for preparing intermediates of formula (III) wherein Y1 is acyloxy, wherein acyl is of the formula R—C(O)—, wherein R is alkyl of 1-6 carbon atoms, Y2 is aralkyloxy, and Z is benzoyloxy or acyloxy, wherein acyl is as defined above. Intermediates of formula (III) are useful in a novel process for preparing the mono-L-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol (ganciclovir). The mono-L-valine ester of ganciclovir and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.