发明授权
US06221871B1 Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands
失效
某些氨基甲基联苯,氨基甲基苯基吡啶和氨基甲基苯基嘧啶衍生物; 新型多巴胺受体亚型选择性配体
- 专利标题: Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands
- 专利标题(中): 某些氨基甲基联苯,氨基甲基苯基吡啶和氨基甲基苯基嘧啶衍生物; 新型多巴胺受体亚型选择性配体
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申请号: US09330513申请日: 1999-06-11
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公开(公告)号: US06221871B1公开(公告)日: 2001-04-24
- 发明人: Jun Yuan , Andrew Thurkauf
- 申请人: Jun Yuan , Andrew Thurkauf
- 主分类号: A61K31505
- IPC分类号: A61K31505
摘要:
Disclosed are compounds of the formula: where S and V are various organic or inorganic substituents; G and K are the same or different and represent N or CR′ where R′ is an organic or inorganic substituent; R is hydrogen or an alkyl group; R1, X, Y, Z and T are organic or inorganic substituents; and R2 and R3 represent hydrogen or organic substituents; or NR2R3 together represents a heterocyclic ring system; and the pharmaceutically acceptable salts thereof; which are highly selective partial agonists or antagonists at brain dopamine receptor subtypes and, thus, are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.
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