发明授权
US06229029B1 11&bgr;-aryl substituted 14,17-ethanoestratriens, method for the production of these compounds and their use in the production of medicaments
失效
11β-芳基取代的14,17-乙炔雌酮，这些化合物的生产方法及其在制备药物中的用途
- 专利标题： 11&bgr;-aryl substituted 14,17-ethanoestratriens, method for the production of these compounds and their use in the production of medicaments
- 专利标题（中）： 11β-芳基取代的14,17-乙炔雌酮，这些化合物的生产方法及其在制备药物中的用途
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申请号： US09424913申请日： 2000-06-09
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公开(公告)号： US06229029B1公开(公告)日： 2001-05-08
- 发明人: Rolf Bohlmann , Karl Heinrich Fritzemeier , Christa Hegele-Hartung , Rudolf Knauthe , Karsten Parzcyk
- 申请人： Rolf Bohlmann , Karl Heinrich Fritzemeier , Christa Hegele-Hartung , Rudolf Knauthe , Karsten Parzcyk
- 优先权： DE19724187 19970602
- 主分类号： C07D24500
- IPC分类号： C07D24500
摘要：
This invention describes 11&bgr;-aryl-substituted 14,17-ethanoestratrienes of general formula (I). The new compounds are selective estrogens whose action occurs in a tissue-selective manner. The estrogenic action occurs in particular on bone, in the cardiovascular system and in the CNS (central nervous system). Only a slight estrogenic action or no estrogenic action occurs in the uterus and in the liver, however. The compounds are suitable for the production of pharmaceutical agents for use in numerous indications (for example for hormone replacement therapy, prevention and treatment of osteoporosis).
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