发明授权
- 专利标题: Benzimidazole derivatives, their production and use
- 专利标题(中): 苯并咪唑衍生物,其生产和使用
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申请号: US09376494申请日: 1999-08-18
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公开(公告)号: US06232334B1公开(公告)日: 2001-05-15
- 发明人: Takehiko Naka , Kohei Nishikawa , Takeshi Kato
- 申请人: Takehiko Naka , Kohei Nishikawa , Takeshi Kato
- 优先权: JP2-113148 19900427; JP2-141942 19900530; JP2-208662 19900806; JP2-264579 19901001; JP2-413679 19901224
- 主分类号: A61K314184
- IPC分类号: A61K314184
摘要:
Benzimidazole derivatives of the formula (I): wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R′ group; R1 is hydrogen or an optionally substituted hydrocarbon residue; R2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R′ is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is —O—, —S(O)m— or —N(R4)— wherein m is an integer of 0, 1 or 2 and R4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases, strokes, cerebral apoplexy and nephritis.
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