利索-全球专利检索

  1. 登录
  2. 注册
发明授权
US06235752B1 Isoquinolinamine and phthalazinamine derivatives which interact with CRF receptors 失效
与CRF受体相互作用的异喹啉胺和酞嗪胺衍生物

  • 专利标题： Isoquinolinamine and phthalazinamine derivatives which interact with CRF receptors
  • 专利标题（中）： 与CRF受体相互作用的异喹啉胺和酞嗪胺衍生物
  • 申请号： US09331380
    申请日： 1999-09-20
  • 公开(公告)号： US06235752B1
    公开(公告)日： 2001-05-22
  • 发明人: Jun Yuan , Taeyoung Yoon
  • 申请人： Jun Yuan , Taeyoung Yoon
  • 主分类号： A61K3147
  • IPC分类号： A61K3147
Isoquinolinamine and phthalazinamine derivatives which interact with CRF receptors
摘要：
Disclosed are compounds that are highly selective partial agonists or antagonists of CRF1 receptors. The disclosed compounds are useful in the diagnosis and treatment of stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache, and anxiety. The compounds are represented by the formula wherein R1, R2, R3, R4, and Ar represent various inorganic and organic substituents. Also disclosed are pharmaceutical compositions and methods of treating post traumatic stress disorder, depression, headache, and anxiety.
摘要（中）：

公开了作为CRF1受体的高选择性部分激动剂或拮抗剂的化合物。 所公开的化合物可用于诊断和治疗应激相关疾病如创伤后应激障碍（PTSD）以及抑郁，头痛和焦虑。 这些化合物由化学式R 1表示，R 2，R 3，R 4和Ar表示各种无机和有机取代基。还公开了治疗创伤后应激障碍，抑郁症，头痛和焦虑的药物组合物和方法。

信息查询
Espacenet
0/0