发明授权
US06235922B1 Processes and intermediates for preparing benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
失效
制备用于抑制ACE和NEP的苯并稠合氮杂酮和哌啶酮化合物的方法和中间体
- 专利标题： Processes and intermediates for preparing benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
- 专利标题（中）： 制备用于抑制ACE和NEP的苯并稠合氮杂酮和哌啶酮化合物的方法和中间体
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申请号： US09205316申请日： 1998-12-04
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公开(公告)号： US06235922B1公开(公告)日： 2001-05-22
- 发明人: Jeffrey A. Robl , Chong-Qing Sun
- 申请人： Jeffrey A. Robl , Chong-Qing Sun
- 主分类号： C07C32734
- IPC分类号： C07C32734
摘要：
Compounds having the following formula I, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: wherein: Y1 and Y2 are each independently hydrogen, alkyl, aryl, halogen, or alkoxy; X is O or S(O)t; A is t is zero, one or two; m and n are independently zero or one; and wherein R, R5, R5a, R5b, R6, R7, R11, q and r are defined herein.
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