发明授权
- 专利标题： Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
- 专利标题（中）： 阿奇霉素一水合物异丙醇包合物及其制备方法
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申请号： US09373549申请日： 1999-08-13
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公开(公告)号： US06245903B1公开(公告)日： 2001-06-12
- 发明人: Khashayar Karimian , Mehrnoush Motamedi
- 申请人： Khashayar Karimian , Mehrnoush Motamedi
- 优先权： CA2245398 19980821
- 主分类号： C07H1708
- IPC分类号： C07H1708
摘要：
A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate) has been obtained. Preparation of the novel form of azithromycin comprises the steps of dissolving azithromycin in isopropanol, followed by the slow addition of water to the organic solution.
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