发明授权
US06248757B1 3-(Pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3H)-one derivatives and their use as 5-HT4 ligands
失效
3-（吡咯烷-3-基）-1,3,4-恶二唑-2（3H） - 酮衍生物及其作为5-HT 4配体的用途
- 专利标题： 3-(Pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3H)-one derivatives and their use as 5-HT4 ligands
- 专利标题（中）： 3-（吡咯烷-3-基）-1,3,4-恶二唑-2（3H） - 酮衍生物及其作为5-HT 4配体的用途
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申请号： US09403779申请日： 1999-11-04
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公开(公告)号： US06248757B1公开(公告)日： 2001-06-19
- 发明人: Alistair Lochead , Samir Jegham , Jean Jeunesse
- 申请人： Alistair Lochead , Samir Jegham , Jean Jeunesse
- 优先权： FR9705539 19970506
- 主分类号： A61K31445
- IPC分类号： A61K31445
摘要：
Compounds corresponding to the general formula (I) in which R1 represents hydrogen or an alkyl or cycloalkylmethyl group, X1 represents hydrogen or a halogen or an alkoxy group, or alternatively OR1 and X1 together represent a group of formula —OCH2O—, —O(CH2)2—, —O(CH2)3—, —O(CH2)2O— or —O(CH2)3O—, X2 represents hydrogen, an amino group or a group of general formula —NHCO2R in which R represents an alkyl or phenylalkyl group, X3 represents hydrogen or a halogen, and R2 represents hydrogen or an alkyl, phenylalkyl or [(4-dimethylamino)piperid-1-ylcarbonyl]alkyl group. Therapeutic application.
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