发明授权
- 专利标题： Polycationic polymers
- 专利标题（中）： 聚阳离子聚合物
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申请号： US08910647申请日： 1997-08-13
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公开(公告)号： US06251433B1公开(公告)日： 2001-06-26
- 发明人: Ronald N. Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael A. Innis , John E. Murphy , Fred E. Cohen , Tetsuo Uno
- 申请人： Ronald N. Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael A. Innis , John E. Murphy , Fred E. Cohen , Tetsuo Uno
- 主分类号： A61F914
- IPC分类号： A61F914
摘要：
This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
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