A system for reducing internal interference in a radio-frequency (RF) receiver includes providing a plurality of time slots within a frame where the receiver is configured to receive external RF signals during a receive time slot within the frame. External RF signals are the prevented from reaching a front-end portion of the receiver and the receiver is activated, and a predetermined period of time is permitted to elapse to permit the receiver to settle. An interference data collection is performed during a period of time prior to a predetermined receive time slot where the data collected represents internally generated interference signals. The data collected during the interference data collection is processed to determine a bias value corresponding to the interference signals, and the receiver is then permitted to receive external RF signals during the predetermined receive time slot so that data is collected during the predetermined receive time slot. The data collected during the predetermined receive time slot is processed and the bias value is subtracted from the data collected to provide output data corresponding to the external RF signals absent the interference signals.