发明授权
US06262123B1 Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
失效
正离子取代的苯甲酰胍，其制备方法，它们作为药物或诊断剂的用途，以及包含它们的药物
- 专利标题： Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
- 专利标题（中）： 正离子取代的苯甲酰胍，其制备方法，它们作为药物或诊断剂的用途，以及包含它们的药物
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申请号： US09398196申请日： 1999-09-17
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公开(公告)号： US06262123B1公开(公告)日： 2001-07-17
- 发明人: Udo Albus , Joachim Brendel , Heinz-Werner Kleemann , Hans Jochen Lang , Wolfgang Scholz , Jan-Robert Schwark , Andreas Weichert
- 申请人： Udo Albus , Joachim Brendel , Heinz-Werner Kleemann , Hans Jochen Lang , Wolfgang Scholz , Jan-Robert Schwark , Andreas Weichert
- 优先权： DE19608161 19960304
- 主分类号： A61K31165
- IPC分类号： A61K31165
摘要：
Ortho-substituted benzoylguanidines of the formula I in which R(1) to R(4) have the meanings given in the claims, are suitable, as antiarrhythmic pharmaceuticals having a cardioprotective component, for the prophylaxis and treatment of infarction and for the treatment of angina pectoris. They also inhibit, in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the triggering of ischemically induced cardiac arrhythmias.
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